{"metadata":{"accession":"PF11952","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021859","hierarchy":null,"name":{"name":"XRN-Two Binding Domain, XTBD","short":"XTBD"},"description":[{"text":"<p>XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1 [[cite:PUB00075685]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075685":{"PMID":24462208,"ISBN":null,"volume":"53","issue":"2","year":2014,"title":"PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain.","URL":null,"raw_pages":"351-60","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Miki TS","Richter H","Ruegger S","Großhans H."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2014.01.001"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":58,"interactions":0,"matches":2439,"pathways":0,"proteins":2436,"proteomes":1174,"sets":0,"structural_models":{"alphafold":2113},"structures":1,"taxa":3853},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":1848},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}