{"metadata":{"accession":"PF11945","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021854","hierarchy":null,"name":{"name":"WAHD domain of WASH complex","short":"WASH_WAHD"},"description":[{"text":"<p>This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see [pfam:PF04062]. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00057271":{"PMID":19922874,"ISBN":null,"volume":"17","issue":"5","year":2009,"title":"A FAM21-containing WASH complex regulates retromer-dependent sorting.","URL":null,"raw_pages":"699-711","medline_journal":"Dev Cell","ISO_journal":"Dev. Cell","authors":["Gomez TS","Billadeau DD."],"DOI_URL":"http://dx.doi.org/10.1016/j.devcel.2009.09.009"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":24,"interactions":0,"matches":1881,"pathways":0,"proteins":1850,"proteomes":1325,"sets":0,"structural_models":{"alphafold":1638},"structures":0,"taxa":4376},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":1469},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}