{"metadata":{"accession":"PF11935","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR032460","hierarchy":null,"name":{"name":"Symplekin/PTA1 N-terminal","short":"SYMPK_PTA1_N"},"description":[{"text":"<p>This is the N-terminal domain found in the symplekin protein from animals and PTA1 protein from budding yeasts and is typically between 239 to 261 amino acids in length. Symplekin is a scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing [[cite:PUB00068954],[cite:PUB00068955]]. PTA1 is involved in pre-tRNA processing. PTA1 is a subunit of the cleavage and polyadenylation factor (CPF), which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB [[cite:PUB00070276]]. This domain has the ARM or HEAT fold, with seven pairs of antiparallel alpha-helices arranged in the shape of an arc. It is important for interaction with Ssu72 and stimulates Ssu72 C-terminal domain phosphatase activity in vitro [[cite:PUB00065426]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00068954":{"PMID":18042462,"ISBN":null,"volume":"28","issue":"4","year":2007,"title":"A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing.","URL":null,"raw_pages":"692-9","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Wagner EJ","Burch BD","Godfrey AC","Salzler HR","Duronio RJ","Marzluff WF."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2007.10.009"},"PUB00065426":{"PMID":20861839,"ISBN":null,"volume":"467","issue":"7316","year":2010,"title":"Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.","URL":null,"raw_pages":"729-33","medline_journal":"Nature","ISO_journal":"Nature","authors":["Xiang K","Nagaike T","Xiang S","Kilic T","Beh MM","Manley JL","Tong L."],"DOI_URL":"http://dx.doi.org/10.1038/nature09391"},"PUB00068955":{"PMID":19450530,"ISBN":null,"volume":"34","issue":"3","year":2009,"title":"A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs.","URL":null,"raw_pages":"322-32","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Sullivan KD","Steiniger M","Marzluff WF."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2009.04.024"},"PUB00070276":{"PMID":12819204,"ISBN":null,"volume":"278","issue":"35","year":2003,"title":"Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends.","URL":null,"raw_pages":"33000-10","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Nedea E","He X","Kim M","Pootoolal J","Zhong G","Canadien V","Hughes T","Buratowski S","Moore CL","Greenblatt J."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M304454200"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":70,"interactions":0,"matches":4686,"pathways":0,"proteins":4626,"proteomes":2872,"sets":1,"structural_models":{"alphafold":3038},"structures":18,"taxa":7645},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":88,"alignment:full":3427},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4h3k","name":"Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA polymerase II CTD peptide phosphorylated at Ser-2, Ser-5 and Ser-7"}}}