{"metadata":{"accession":"PF11931","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024598","hierarchy":null,"name":{"name":"SF3a60/Prp9 C-terminal","short":"SF3a60_Prp9_C"},"description":[{"text":"<p>This domain corresponds to the C-terminal region of SF3a60 subunit (Prp9 in yeast counterpart) from the highly conserved heterotrimeric complex SF3a found in eukaryotes. It is essential for pre-mRNA splicing that functions in spliceosome assembly within the mature U2 snRNP (small ribonucleoprotein particle). This domain has two conserved sequence motifs: PIP and CEICG. It contains a zinc-finger domain of the C2H2-type which might be important for RNA binding and protein-protein interactions with components of the SF3b complex [[cite:PUB00059480]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00059480":{"PMID":22314233,"ISBN":null,"volume":"31","issue":"6","year":2012,"title":"Structure and assembly of the SF3a splicing factor complex of U2 snRNP.","URL":null,"raw_pages":"1579-90","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Lin PC","Xu RM."],"DOI_URL":"http://dx.doi.org/10.1038/emboj.2012.7"}},"set_info":{"accession":"CL0361","name":"C2H2-zf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":99,"interactions":0,"matches":4116,"pathways":0,"proteins":4089,"proteomes":3337,"sets":1,"structural_models":{"alphafold":3491},"structures":52,"taxa":8787},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":66,"alignment:full":3158},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}