{"metadata":{"accession":"PF11928","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021849","hierarchy":null,"name":{"name":"Early growth response N-terminal domain","short":"DUF3446"},"description":[{"text":"<p>Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases [[cite:PUB00086408]]. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators [[cite:PUB00086407]]. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with [pfam:PF00096].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086408":{"PMID":25999311,"ISBN":null,"volume":"589","issue":"15","year":2015,"title":"Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1.","URL":null,"raw_pages":"1748-53","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Zandarashvili L","White MA","Esadze A","Iwahara J."],"DOI_URL":"https://doi.org/10.1016/j.febslet.2015.05.022"},"PUB00086407":{"PMID":21836637,"ISBN":null,"volume":"12","issue":"10","year":2011,"title":"The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.","URL":null,"raw_pages":"1018-23","medline_journal":"EMBO Rep","ISO_journal":"EMBO Rep.","authors":["Garcia-Gutierrez P","Juarez-Vicente F","Gallardo-Chamizo F","Charnay P","Garcia-Dominguez M."],"DOI_URL":"https://doi.org/10.1038/embor.2011.152"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":14,"interactions":0,"matches":2576,"pathways":0,"proteins":2563,"proteomes":717,"sets":0,"structural_models":{"alphafold":2221},"structures":2,"taxa":2470},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":1927},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}