{"metadata":{"accession":"PF11919","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021843","hierarchy":null,"name":{"name":"Proteasome activator complex subunit 4-like, C-terminal","short":"PSME4_C"},"description":[{"text":"<p>This domain is found at the C-terminal end of human Proteasome activator complex subunit 4 (PSME4) and similar sequences from eukaryotes. PSME4 is an associated component of the proteasome that specifically recognises acetylated histones and promotes ATP- and ubiquitin -independent degradation of core histones during spermatogenesis and DNA damage response. This protein adopts a dome-like structure composed of HEAT repeat-like modules and a C-terminal domain that contains a hydrophobic -tyrosine-other motif (this entry). This domain, which adopts an all-alpha structure, is responsible for the interaction with the alpha-ring surface of the 20S [[cite:PUB00155659]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155659":{"PMID":32134919,"ISBN":null,"volume":"18","issue":"3","year":2020,"title":"Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures.","URL":null,"raw_pages":"e3000654","medline_journal":"PLoS Biol","ISO_journal":"PLoS Biol","authors":["Guan H","Wang Y","Yu T","Huang Y","Li M","Saeed AFUH","Perculija V","Li D","Xiao J","Wang D","Zhu P","Ouyang S."],"DOI_URL":"https://doi.org/10.1371/journal.pbio.3000654"},"PUB00076285":{"PMID":20227375,"ISBN":null,"volume":"37","issue":"5","year":2010,"title":"Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.","URL":null,"raw_pages":"728-35","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Sadre-Bazzaz K","Whitby FG","Robinson H","Formosa T","Hill CP."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2010.02.002"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":74,"interactions":0,"matches":4782,"pathways":0,"proteins":4775,"proteomes":3014,"sets":0,"structural_models":{"alphafold":412},"structures":9,"taxa":7986},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":81,"alignment:full":3692},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}