{"metadata":{"accession":"PF11904","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR055285","hierarchy":null,"name":{"name":"ANKRD13 C-terminal","short":"ANKRD13_C"},"description":[{"text":"<p>This domain, and the associated ANK family repeat [pfam:PF00023] domain, are found in ANKRD13 of which at least 4 subtypes are known to exist, termed A-D. ANKRD13C act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2 [[cite:PUB00057233]]. ANKRD13A/B/D are ubiquitin-binding proteins that specifically  recognise and bind Lys-63-linked ubiquitin. They positively regulate the internalisation of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane [[cite:PUB00155297]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00057233":{"PMID":20959461,"ISBN":null,"volume":"285","issue":"52","year":2010,"title":"ANKRD13C acts as a molecular chaperone for G protein-coupled receptors.","URL":null,"raw_pages":"40838-51","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Parent A","Roy SJ","Iorio-Morin C","Lepine MC","Labrecque P","Gallant MA","Slipetz D","Parent JL."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M110.142257"},"PUB00155297":{"PMID":22298428,"ISBN":null,"volume":"23","issue":"7","year":2012,"title":"The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane.","URL":null,"raw_pages":"1343-53","medline_journal":"Mol Biol Cell","ISO_journal":"Mol Biol Cell","authors":["Tanno H","Yamaguchi T","Goto E","Ishido S","Komada M."],"DOI_URL":"https://doi.org/10.1091/mbc.E11-09-0817"}},"set_info":{"accession":"CL0048","name":"LolA_LolB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":117,"interactions":0,"matches":9113,"pathways":0,"proteins":8651,"proteomes":1827,"sets":1,"structural_models":{"alphafold":7470},"structures":0,"taxa":5655},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":80,"alignment:full":6856},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}