{"metadata":{"accession":"PF11901","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR006616","hierarchy":null,"name":{"name":"DM9 repeat","short":"DM9"},"description":[{"text":"<p>This repeat of unknown function was first identified in Diptera proteins; later on it was found in a wide range of invertebrates and vertebrates [[cite:PUB00101198]], such as natterin [[cite:PUB00056184],[cite:PUB00101201]]. It is often present in proteins comprising only two or four DM9 repeats and occasionally is linked to other domains at its N- or C-terminal. In the mannose-specific lectin CGL1 from Crassostrea gigas, DM9 exhibits high binding specificity and avidity toward D-mannose residue and served as a pattern recognition receptor (PRR) with a broad range of recognition spectrum to various pathogen-associated molecular patterns [[cite:PUB00101199]]. It also mediates immune recognition and cellular encapsulation [[cite:PUB00101200]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101201":{"PMID":34437409,"ISBN":null,"volume":"13","issue":"8","year":2021,"title":"The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function. ","URL":null,"raw_pages":"538","medline_journal":"Toxins (Basel)","ISO_journal":"Toxins (Basel)","authors":["Lima C","Disner GR","Falcao MAP","Seni-Silva AC","Maleski ALA","Souza MM","Reis Tonello MC","Lopes-Ferreira M."],"DOI_URL":null},"PUB00101199":{"PMID":27377186,"ISBN":null,"volume":"6","issue":null,"year":2016,"title":"Identification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Mannose-Specific Lectin CGL1 from the Pacific Oyster Crassostrea gigas.","URL":null,"raw_pages":"29135","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Unno H","Matsuyama K","Tsuji Y","Goda S","Hiemori K","Tateno H","Hirabayashi J","Hatakeyama T."],"DOI_URL":null},"PUB00101200":{"PMID":33242570,"ISBN":null,"volume":"116","issue":null,"year":2021,"title":"A DM9-containing protein from oyster Crassostrea gigas (CgDM9CP-3) mediating immune recognition and encapsulation.","URL":null,"raw_pages":"103937","medline_journal":"Dev Comp Immunol","ISO_journal":"Dev Comp Immunol","authors":["Liu Y","Wang W","Zhao Q","Yuan P","Li J","Song X","Liu Z","Ding D","Wang L","Song L."],"DOI_URL":null},"PUB00101198":{"PMID":29238341,"ISBN":null,"volume":"8","issue":null,"year":2017,"title":"DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum.","URL":null,"raw_pages":"1607","medline_journal":"Front Immunol","ISO_journal":"Front Immunol","authors":["Jiang S","Wang L","Huang M","Jia Z","Weinert T","Warkentin E","Liu C","Song X","Zhang H","Witt J","Qiu L","Peng G","Song L."],"DOI_URL":null},"PUB00056184":{"PMID":16054523,"ISBN":null,"volume":"87","issue":"8","year":2005,"title":"Natterins, a new class of proteins with kininogenase activity characterized from Thalassophryne nattereri fish venom.","URL":null,"raw_pages":"687-99","medline_journal":"Biochimie","ISO_journal":"Biochimie","authors":["Magalhaes GS","Lopes-Ferreira M","Junqueira-de-Azevedo IL","Spencer PJ","Araujo MS","Portaro FC","Ma L","Valente RH","Juliano L","Fox JW","Ho PL","Moura-da-Silva AM."],"DOI_URL":"http://dx.doi.org/10.1016/j.biochi.2005.03.016"}},"set_info":{"accession":"CL0843","name":"MFPT-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":195,"interactions":0,"matches":5400,"pathways":0,"proteins":4828,"proteomes":1163,"sets":1,"structural_models":{"alphafold":4123},"structures":10,"taxa":3688},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":114,"alignment:full":4682},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8jea","name":"Crystal structure of CGL1 from Crassostrea gigas, mannotriose-bound form (CGL1/Man(alpha)1-2Man(alpha)1-2Man)"}}}