{"metadata":{"accession":"PF11892","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021826","hierarchy":null,"name":{"name":"Pyrimidine/purine nucleotide monophosphate nucleosidase, C-terminal","short":"PpnN_C"},"description":[{"text":"<p>This domain is found at the C-terminal end of Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase from Escherichia coli (PpnN, also known as YgdH) and similar proteins mainly found in gammaproteobacteria. PpnN is a nucleosidase that catalyses the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates. The binding of (p)ppGpp, an alarmone molecule that plays a role in the bacterial stringent response, gives rise to a large conformational change in the terminal region that leads to the exposure of the catalytic pocket. This domain shows a completely alpha-helical fold with an extension that wraps around the central domain [[cite:PUB00100958],[cite:PUB00084997]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100958":{"PMID":31023582,"ISBN":null,"volume":"74","issue":"6","year":2019,"title":"(p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch.","URL":null,"raw_pages":"1239-1249.e4","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Zhang YE","Bærentsen RL","Fuhrer T","Sauer U","Gerdes K","Brodersen DE."],"DOI_URL":null},"PUB00084997":{"PMID":27941785,"ISBN":null,"volume":"14","issue":"2","year":2017,"title":"Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.","URL":null,"raw_pages":"187-194","medline_journal":"Nat Methods","ISO_journal":"Nat. Methods","authors":["Sevin DC","Fuhrer T","Zamboni N","Sauer U."],"DOI_URL":"https://doi.org/10.1038/nmeth.4103"}},"set_info":{"accession":"CL0349","name":"SLOG"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":2629,"pathways":0,"proteins":2629,"proteomes":2622,"sets":1,"structural_models":{"alphafold":1597},"structures":9,"taxa":3451},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":45,"alignment:full":887},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}