{"metadata":{"accession":"PF11878","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021816","hierarchy":null,"name":{"name":"Dedicator of cytokinesis C/D, N terminal","short":"DOCK_C-D_N"},"description":[{"text":"<p>This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8) and DOCK-D subfamily (DOCK 9, 10, 11). DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [[cite:PUB00014935],[cite:PUB00073863]], required during several cellular processes, such as cell motility and phagocytosis. DOCK proteins are categorised into four subfamilies based on their sequence homology: DOCK-A (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [[cite:PUB00014935]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00073863":{"PMID":25022758,"ISBN":null,"volume":"93","issue":"10-12","year":2014,"title":"Dock-family exchange factors in cell migration and disease.","URL":null,"raw_pages":"466-77","medline_journal":"Eur J Cell Biol","ISO_journal":"Eur. J. Cell Biol.","authors":["Gadea G","Blangy A."],"DOI_URL":"http://dx.doi.org/10.1016/j.ejcb.2014.06.003"},"PUB00014935":{"PMID":12432077,"ISBN":null,"volume":"115","issue":"Pt 24","year":2002,"title":"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.","URL":null,"raw_pages":"4901-13","medline_journal":"J Cell Sci","ISO_journal":"J. Cell. Sci.","authors":["Cote JF","Vuori K."],"DOI_URL":"http://dx.doi.org/10.1242/jcs.00219"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":119,"interactions":0,"matches":12101,"pathways":0,"proteins":12034,"proteomes":1245,"sets":0,"structural_models":{"alphafold":701},"structures":7,"taxa":4049},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":9594},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}