{"metadata":{"accession":"PF11876","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021815","hierarchy":null,"name":{"name":"Type VI immunity for VRR-NUC","short":"TsiV"},"description":[{"text":"<p>This entry represents bacterial immunity proteins that in are encoded by the PAAR2 cluster [[cite:PUB00103837]] and have been named Type VI immunity for VRR-NUC (TsiV). These proteins form an effector-immunity pair with TseV (type VI effector VRR-NUC), the TseV-TsiV pair [[cite:PUB00103837],[cite:PUB00103836]]. These are alpha+beta class of proteins whose surface is mainly electronegative with a a hydrophobic core formed by the N-terminal region [[cite:PUB00103837]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00103837":{"PMID":33838074,"ISBN":null,"volume":"288","issue":"19","year":2021,"title":"The Pseudomonas aeruginosa PAAR2 cluster encodes a putative VRR-NUC domain-containing effector.","URL":null,"raw_pages":"5755-5767","medline_journal":"FEBS J","ISO_journal":"FEBS J","authors":["Wang S","Geng Z","Zhang H","She Z","Dong Y."],"DOI_URL":null},"PUB00103836":{"PMID":36226828,"ISBN":null,"volume":"11","issue":null,"year":2022,"title":"Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases.","URL":null,"raw_pages":"e82437","medline_journal":"Elife","ISO_journal":"Elife","authors":["Hespanhol JT","Sanchez-Limache DE","Nicastro GG","Mead L","Llontop EE","Chagas-Santos G","Farah CS","de Souza RF","Galhardo RDS","Lovering AL","Bayer-Santos E."],"DOI_URL":null}},"set_info":{"accession":"CL0961","name":"TsiV_TsiT-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":1088,"pathways":0,"proteins":1059,"proteomes":418,"sets":1,"structural_models":{"alphafold":622},"structures":1,"taxa":775},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":314},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7drg","name":"Pseudomonas aeruginosa T6SS protein PA0821"}}}