{"metadata":{"accession":"PF11873","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024570","hierarchy":null,"name":{"name":"Membrane-bound lytic murein transglycosylase C, N-terminal domain","short":"Mltc_N"},"description":[{"text":"<p>This domain is found associated with [pfam:PF01464]. It is the N-terminal structural domain of MltC (Membrane-bound lytic murein transglycosylase C), one of the seven lytic transglycosylases found in the genome of the Gram-negative bacterium Escherichia coli. The role of the N-terminal domain is suggested to be important not as a mere structural extension of the active site beyond what is seen in other lytic transglycosylases but one that creates a peptide-binding site at position +2 [[cite:PUB00109606]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00109606":{"PMID":24988330,"ISBN":null,"volume":"9","issue":"9","year":2014,"title":"Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli.","URL":null,"raw_pages":"2058-66","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem Biol","authors":["Artola-Recolons C","Lee M","Bernardo-Garcia N","Blazquez B","Hesek D","Bartual SG","Mahasenan KV","Lastochkin E","Pi H","Boggess B","Meindl K","Uson I","Fisher JF","Mobashery S","Hermoso JA."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":1266,"pathways":0,"proteins":1266,"proteomes":1161,"sets":0,"structural_models":{"alphafold":845},"structures":4,"taxa":1815},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":443},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}