{"metadata":{"accession":"PF11870","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024569","hierarchy":null,"name":{"name":"Lactate utilisation protein B, C-terminal","short":"LutB_C"},"description":[{"text":"<p>This domain is functionally uncharacterised. This domain is found at the C-terminal of a family of 4Fe-4S, iron-sulphur cluster binding proteins, including Lactate utilisation protein B (LutB). These proteins have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4Fe-4S iron-sulphur clusters. This domain is found in LutB proteins in association with the LUD domain ([pfam:PF02589]) and usually Fer4_8 ([pfam:PF13183]). The LutABC operon is involved in lactate-utilisation and is essential [[cite:PUB00076952],[cite:PUB00053899]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00076952":{"PMID":24274019,"ISBN":null,"volume":"14","issue":null,"year":2013,"title":"LUD, a new protein domain associated with lactate utilization.","URL":null,"raw_pages":"341","medline_journal":"BMC Bioinformatics","ISO_journal":"BMC Bioinformatics","authors":["Hwang WC","Bakolitsa C","Punta M","Coggill PC","Bateman A","Axelrod HL","Rawlings ND","Sedova M","Peterson SN","Eberhardt RY","Aravind L","Pascual J","Godzik A."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2105-14-341"},"PUB00053899":{"PMID":19201793,"ISBN":null,"volume":"191","issue":"8","year":2009,"title":"A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation.","URL":null,"raw_pages":"2423-30","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Chai Y","Kolter R","Losick R."],"DOI_URL":"http://dx.doi.org/10.1128/JB.01464-08"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":5783,"pathways":0,"proteins":5783,"proteomes":5267,"sets":0,"structural_models":{"alphafold":3480},"structures":0,"taxa":7254},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":2655},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}