{"metadata":{"accession":"PF11865","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024585","hierarchy":null,"name":{"name":"Serine/threonine-protein kinase mTOR domain","short":"mTOR_dom"},"description":[{"text":"<p>This entry represents a domain found in human serine/threonine-protein kinase mTOR and its homologues, a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals [[cite:PUB00151556],[cite:PUB00151557],[cite:PUB00151558],[cite:PUB00151559],[cite:PUB00151555]]. In Saccharomyces cerevisiae, the TOR proteins, TOR1 and TOR2, regulate growth in a rapamycin-sensitive manner [[cite:PUB00015261]]. This domain consists of HEAT repeats [[cite:PUB00103870],[cite:PUB00151560]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151557":{"PMID":31601708,"ISBN":null,"volume":"366","issue":"6464","year":2019,"title":"Structural basis for the docking of mTORC1 on the lysosomal surface.","URL":null,"raw_pages":"468-475","medline_journal":"Science","ISO_journal":"Science","authors":["Rogala KB","Gu X","Kedir JF","Abu-Remaileh M","Bianchi LF","Bottino AMS","Dueholm R","Niehaus A","Overwijn D","Fils AP","Zhou SX","Leary D","Laqtom NN","Brignole EJ","Sabatini DM."],"DOI_URL":"https://doi.org/10.1126/science.aay0166"},"PUB00103870":{"PMID":27909983,"ISBN":null,"volume":"7","issue":"12","year":2016,"title":"4.4 A Resolution Cryo-EM structure of human mTOR Complex 1.","URL":null,"raw_pages":"878-887","medline_journal":"Protein Cell","ISO_journal":"Protein Cell","authors":["Yang H","Wang J","Liu M","Chen X","Huang M","Tan D","Dong MQ","Wong CC","Wang J","Xu Y","Wang HW."],"DOI_URL":null},"PUB00151556":{"PMID":31112131,"ISBN":null,"volume":"8","issue":null,"year":2019,"title":"GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. 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