{"metadata":{"accession":"PF11861","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024576","hierarchy":null,"name":{"name":"Ribosomal RNA methyltransferase Spb1, DUF3381","short":"DUF3381"},"description":[{"text":"<p>This domain is functionally uncharacterised and it is found in the central region of fungal SPB1 and mammalian homologue FTSJ3. This domain is found associated with [pfam:PF07780], [pfam:PF01728]. SPB1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit [[cite:PUB00016377]]. FTSJ3, SPB1 homologue in humans, is associated with NIP7 (involved in the biogenesis of 40S subunit) and functions in pre-rRNA processing [[cite:PUB00068805]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00068805":{"PMID":22195017,"ISBN":null,"volume":"6","issue":"12","year":2011,"title":"The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing.","URL":null,"raw_pages":"e29174","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Morello LG","Coltri PP","Quaresma AJ","Simabuco FM","Silva TC","Singh G","Nickerson JA","Oliveira CC","Moore MJ","Zanchin NI."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pone.0029174"},"PUB00016377":{"PMID":10556316,"ISBN":null,"volume":"27","issue":"23","year":1999,"title":"Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae.","URL":null,"raw_pages":"4598-608","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Kressler D","Rojo M","Linder P","Cruz J."],"DOI_URL":"http://dx.doi.org/10.1093/nar/27.23.4598"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":77,"interactions":0,"matches":3912,"pathways":0,"proteins":3891,"proteomes":3174,"sets":0,"structural_models":{"alphafold":3292},"structures":35,"taxa":8437},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":153,"alignment:full":2966},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}