{"metadata":{"accession":"PF11847","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021798","hierarchy":null,"name":{"name":"Alpha-(1->3)-arabinofuranosyltransferase, N-terminal GT-C domain","short":"GT-C_AftD"},"description":[{"text":"<p>This domain is found at the N-terminal end of alpha-(1->3)- arabinofuranosyltransferase from Mycolicibacterium smegmatis (AftD, [ec:2.4.2.47]), which is involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan -peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. It catalyses the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG [[cite:PUB00086410]]. This domain shows mixed alpha/beta folds homologous to other solved GT-C glycosyltransferase structures [[cite:PUB00155574]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155574":{"PMID":32386575,"ISBN":null,"volume":"78","issue":"4","year":2020,"title":"Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria.","URL":null,"raw_pages":"683-699.e11","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Tan YZ","Zhang L","Rodrigues J","Zheng RB","Giacometti SI","Rosario AL","Kloss B","Dandey VP","Wei H","Brunton R","Raczkowski AM","Athayde D","Catalao MJ","Pimentel M","Clarke OB","Lowary TL","Archer M","Niederweis M","Potter CS","Carragher B","Mancia F."],"DOI_URL":"https://doi.org/10.1016/j.molcel.2020.04.014"},"PUB00086410":{"PMID":19654261,"ISBN":null,"volume":"19","issue":"11","year":2009,"title":"AftD, a novel essential arabinofuranosyltransferase from mycobacteria.","URL":null,"raw_pages":"1235-47","medline_journal":"Glycobiology","ISO_journal":"Glycobiology","authors":["Skovierova H","Larrouy-Maumus G","Zhang J","Kaur D","Barilone N","Kordulakova J","Gilleron M","Guadagnini S","Belanova M","Prevost MC","Gicquel B","Puzo G","Chatterjee D","Brennan PJ","Nigou J","Jackson M."],"DOI_URL":"https://doi.org/10.1093/glycob/cwp116"}},"set_info":{"accession":"CL0111","name":"GT-C"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":18,"interactions":0,"matches":1717,"pathways":0,"proteins":1673,"proteomes":1560,"sets":1,"structural_models":{"alphafold":161},"structures":3,"taxa":1916},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":764},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}