This domain is functionally uncharacterised and is found in eukaryotic proteins, such as TBC1 domain family members 1 and 4. This presumed domain is typically between 50 to 64 amino acids in length. TBC domain proteins may act as GTPase-activating proteins for RAB2A, RAB8A, RAB10 and RAB14 [[cite:PUB00079096]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00079096":{"PMID":15971998,"ISBN":null,"volume":"391","issue":"Pt 1","year":2005,"title":"AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.","URL":null,"raw_pages":"87-93","medline_journal":"Biochem J","ISO_journal":"Biochem. J.","authors":["Miinea CP","Sano H","Kane S","Sano E","Fukuda M","Peranen J","Lane WS","Lienhard GE."],"DOI_URL":"http://dx.doi.org/10.1042/BJ20050887"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":37,"interactions":0,"matches":3675,"pathways":0,"proteins":3672,"proteomes":1039,"sets":0,"structural_models":{"alphafold":2630},"structures":0,"taxa":3476},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":2873},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}