{"metadata":{"accession":"PF11825","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021780","hierarchy":null,"name":{"name":"Nuclear/hormone receptor activator site AF-1","short":"Nuc_recep-AF1"},"description":[{"text":"<p>Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription [[cite:PUB00063250]]. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif [[cite:PUB00063251]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00063251":{"PMID":19321449,"ISBN":null,"volume":"284","issue":"21","year":2009,"title":"TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.","URL":null,"raw_pages":"14147-56","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Rambaud J","Desroches J","Balsalobre A","Drouin J."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M809023200"},"PUB00063250":{"PMID":12893880,"ISBN":null,"volume":"17","issue":"10","year":2003,"title":"Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation.","URL":null,"raw_pages":"1901-9","medline_journal":"Mol Endocrinol","ISO_journal":"Mol. Endocrinol.","authors":["Warnmark A","Treuter E","Wright AP","Gustafsson JA."],"DOI_URL":"http://dx.doi.org/10.1210/me.2002-0384"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":3914,"pathways":0,"proteins":3896,"proteomes":744,"sets":0,"structural_models":{"alphafold":3578},"structures":5,"taxa":2283},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":3107},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}