{"metadata":{"accession":"PF11822","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021777","hierarchy":null,"name":{"name":"SANT and BTB domain regulator of CSR, BTB domain","short":"BTB_SANBR"},"description":[{"text":"<p>Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR [[cite:PUB00099259]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00099259":{"PMID":33831416,"ISBN":null,"volume":"296","issue":null,"year":2021,"title":"The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.","URL":null,"raw_pages":"100625","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Zheng S","Matthews AJ","Rahman N","Herrick-Reynolds K","Sible E","Choi JE","Wishnie A","Ng YK","Rhodes D","Elledge SJ","Vuong BQ."],"DOI_URL":null}},"set_info":{"accession":"CL0033","name":"POZ"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":29,"interactions":0,"matches":1469,"pathways":0,"proteins":1467,"proteomes":934,"sets":1,"structural_models":{"alphafold":1256},"structures":0,"taxa":3290},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":1113},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}