{"metadata":{"accession":"PF11768","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024511","hierarchy":null,"name":{"name":"WD repeat-containing and planar cell polarity effector protein Fritz","short":"Frtz"},"description":[{"text":"<p>Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis  and collective cell movements. In Drosophila melanogaster, fritz  regulates both the location and the number of wing cell  prehair initiation sites [[cite:PUB00069294]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00069294":{"PMID":15654087,"ISBN":null,"volume":"169","issue":"4","year":2005,"title":"The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis.","URL":null,"raw_pages":"2035-45","medline_journal":"Genetics","ISO_journal":"Genetics","authors":["Collier S","Lee H","Burgess R","Adler P."],"DOI_URL":"http://dx.doi.org/10.1534/genetics.104.033381"}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":17,"interactions":0,"matches":1831,"pathways":0,"proteins":1679,"proteomes":1070,"sets":1,"structural_models":{"alphafold":1415},"structures":2,"taxa":3608},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":1365},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}