This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00041407":{"PMID":17174329,"ISBN":null,"volume":"366","issue":"2","year":2007,"title":"The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a new family of beta-grasp proteins.","URL":null,"raw_pages":"375-81","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Wang Z","Potter BM","Gray AM","Sacksteder KA","Geisbrecht BV","Laity JH."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2006.11.039"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":60,"interactions":0,"matches":6649,"pathways":0,"proteins":6617,"proteomes":4704,"sets":0,"structural_models":{"alphafold":4154},"structures":5,"taxa":6583},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":118,"alignment:full":3015},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}