This family of proteins with unknown function appears to be restricted to Proteobacteria. Recently, it was proposed that members of this family along with members of DUF943 ([pfam:PF06092]) should be recognised as a putative toxin-antitoxin pair in which DUF3289 is a homolog of Colicin M and DUF943 ([pfam:PF06092]) acts as its cognate immunity protein [[cite:PUB00154362]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00154362":{"PMID":38658795,"ISBN":null,"volume":null,"issue":null,"year":2024,"title":"Identification of type VI secretion system effector-immunity pairs using structural bioinformatics.","URL":null,"raw_pages":null,"medline_journal":"Mol Syst Biol","ISO_journal":"Mol Syst Biol","authors":["Geller AM","Shalom M","Zlotkin D","Blum N","Levy A."],"DOI_URL":"https://doi.org/10.1038/s44320-024-00035-8"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":21,"interactions":0,"matches":576,"pathways":0,"proteins":555,"proteomes":270,"sets":0,"structural_models":{"alphafold":297},"structures":3,"taxa":501},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":189},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}