{"metadata":{"accession":"PF11630","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024509","hierarchy":null,"name":{"name":"Anti-lipopolysaccharide factor/Scygonadin","short":"Anti-LPS-SCYG"},"description":[{"text":"<p>Anti-lipopolysaccharide factor binds to bacterial LPS and may specifically inhibit the LPS-mediated activation of the hemolymph coagulation. It has a strong antibacterial effect, especially on the growth of Gram-negative bacteria [[cite:PUB00056151],[cite:PUB00056152]]. This entry also includes the antibacterial protein Scygonadin, which has antibacterial activity against the Gram-positive bacterium Micrococcus luteus [[cite:PUB00056153]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00056152":{"PMID":21195157,"ISBN":null,"volume":"50","issue":"3-4","year":2011,"title":"Antibacterial activity of a synthetic peptide that mimics the LPS binding domain of Indian mud crab, Scylla serrata anti-lipopolysaccharide factor (SsALF) also involved in the modulation of vaginal immune functions through NF-kB signaling.","URL":null,"raw_pages":"179-91","medline_journal":"Microb Pathog","ISO_journal":"Microb. Pathog.","authors":["Sharma S","Yedery RD","Patgaonkar MS","Selvaakumar C","Reddy KV."],"DOI_URL":"http://dx.doi.org/10.1016/j.micpath.2010.12.007"},"PUB00056153":{"PMID":17092560,"ISBN":null,"volume":"44","issue":"8","year":2007,"title":"A male-specific expression gene, encodes a novel anionic antimicrobial peptide, scygonadin, in Scylla serrata.","URL":null,"raw_pages":"1961-8","medline_journal":"Mol Immunol","ISO_journal":"Mol. Immunol.","authors":["Wang KJ","Huang WS","Yang M","Chen HY","Bo J","Li SJ","Wang GZ."],"DOI_URL":"http://dx.doi.org/10.1016/j.molimm.2006.09.036"},"PUB00056151":{"PMID":19490944,"ISBN":null,"volume":"27","issue":"2","year":2009,"title":"Identification, cloning, characterization and recombinant expression of an anti-lipopolysaccharide factor from the hemocytes of Indian mud crab, Scylla serrata.","URL":null,"raw_pages":"275-84","medline_journal":"Fish Shellfish Immunol","ISO_journal":"Fish Shellfish Immunol.","authors":["Yedery RD","Reddy KV."],"DOI_URL":"http://dx.doi.org/10.1016/j.fsi.2009.05.009"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":300,"pathways":0,"proteins":295,"proteomes":25,"sets":0,"structural_models":{"alphafold":289},"structures":2,"taxa":182},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":119},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}