This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. This domain is found in a group of bacterial lipoproteins such as YajI from E.coli and SadB from Salmonella typhimurium. SadB is required for proper surface expression of the autotransporter adhesin SadA [[cite:PUB00086613]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00086613":{"PMID":24369174,"ISBN":null,"volume":"289","issue":"11","year":2014,"title":"A trimeric lipoprotein assists in trimeric autotransporter biogenesis in enterobacteria.","URL":null,"raw_pages":"7388-98","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Grin I","Hartmann MD","Sauer G","Hernandez Alvarez B","Schutz M","Wagner S","Madlung J","Macek B","Felipe-Lopez A","Hensel M","Lupas A","Linke D."],"DOI_URL":"https://doi.org/10.1074/jbc.M113.513275"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":385,"pathways":0,"proteins":385,"proteomes":384,"sets":0,"structural_models":{"alphafold":226},"structures":1,"taxa":570},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":110},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}