This domain adopts an immunoglobulin-like beta-sandwich fold and structurally is most similar to fibronectin. This domain is found at the C-terminus of the Listeria monocytogenes InlP protein. This domain shares some similarity with the secretion signal domain of type X secretion systems [pfam:PF18962]. This domain is also found at the C-terminus of likely cell surface proteins suggesting this domain has a similar function.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00153914":{"PMID":29847585,"ISBN":null,"volume":"14","issue":"5","year":2018,"title":"Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing.","URL":null,"raw_pages":"e1007094","medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog","authors":["Faralla C","Bastounis EE","Ortega FE","Light SH","Rizzuto G","Gao L","Marciano DK","Nocadello S","Anderson WF","Robbins JR","Theriot JA","Bakardjiev AI."],"DOI_URL":"https://doi.org/10.1371/journal.ppat.1007094"}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":290,"pathways":0,"proteins":290,"proteomes":156,"sets":1,"structural_models":{"alphafold":200},"structures":4,"taxa":281},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":145},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3d33","name":"Crystal structure of a duf3244 family protein with an immunoglobulin-like beta-sandwich fold (bvu_0276) from bacteroides vulgatus atcc 8482 at 1.70 A resolution"}}}