This family of proteins with unknown function appears to be restricted to Mycoplasma and Ruminococcus spp. The structure of Uncharacterized protein MG376 homolog from Mycoplasma pneumoniae shows an OB fold with six beta-strands and three loops forming a beta-barrel that is capped by one alpha-helix [[cite:PUB00041476]]. Its specific function is still unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00041476":{"PMID":17348019,"ISBN":null,"volume":"67","issue":"3","year":2007,"title":"Crystal structure of a novel single-stranded DNA binding protein from Mycoplasma pneumoniae.","URL":null,"raw_pages":"776-82","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Das D","Hyun H","Lou Y","Yokota H","Kim R","Kim SH."],"DOI_URL":"http://dx.doi.org/10.1002/prot.21340"}},"set_info":{"accession":"CL0021","name":"OB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":9,"pathways":0,"proteins":9,"proteomes":9,"sets":1,"structural_models":{"alphafold":8},"structures":1,"taxa":32},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":5},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2hql","name":"Crystal structure of a small single-stranded DNA binding protein from Mycoplasma pneumoniae"}}}