{"metadata":{"accession":"PF11503","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021591","hierarchy":null,"name":{"name":"YNR034W-A-like","short":"YNR034W-A-like"},"description":[{"text":"<p>This family of proteins is predominantly found in Saccharomycetales, including YNR034W-A (also known as Ego4) and YCR075W-A (Ego2) from Saccharomyces cerevisiae. Ego2 is a component of the yeast EGO complex (EGOC), which is responsible for the amino acid-dependent activation of the target of rapamycin complex 1 (TORC1). Ego2 adopts a Roadblock domain fold that consists of a central core beta-sheet of five anti-parallel beta-strands flanked by a long alpha-helix on the bottom side. Ego4 shows a similar configuration. It interacts with the GTPase Gtr2, but its specific function remains unknown [[cite:PUB00100978],[cite:PUB00100979]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100979":{"PMID":26206314,"ISBN":null,"volume":"25","issue":"9","year":2015,"title":"Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.","URL":null,"raw_pages":"1043-59","medline_journal":"Cell Res","ISO_journal":"Cell Res","authors":["Powis K","Zhang T","Panchaud N","Wang R","De Virgilio C","Ding J."],"DOI_URL":null},"PUB00100978":{"PMID":31579828,"ISBN":null,"volume":"5","issue":"9","year":2019,"title":"Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases.","URL":null,"raw_pages":"eaax8164","medline_journal":"Sci Adv","ISO_journal":"Sci Adv","authors":["Zhang T","Peli-Gulli MP","Zhang Z","Tang X","Ye J","De Virgilio C","Ding J."],"DOI_URL":null}},"set_info":{"accession":"CL0431","name":"PF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":68,"pathways":0,"proteins":68,"proteomes":49,"sets":1,"structural_models":{"alphafold":59},"structures":5,"taxa":104},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":36},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}