{"metadata":{"accession":"PF11443","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR058580","hierarchy":null,"name":{"name":"Domain of unknown function (DUF2828)","short":"DUF2828"},"description":[{"text":"<p>This is a uncharacterised domain found in eukaryotes and viruses. According to structure predictions and comparison, this domain may have a alpha-helical fold closely related to the TROVE domain suggesting possible involvement in RNA binding [[cite:PUB00152793]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00152793":{"PMID":36419248,"ISBN":null,"volume":"32","issue":"1","year":2023,"title":"DALI shines a light on remote homologs: One hundred discoveries.","URL":null,"raw_pages":"e4519","medline_journal":"Protein Sci","ISO_journal":"Protein Sci","authors":["Holm L","Laiho A","Toronen P","Salgado M."],"DOI_URL":"https://doi.org/10.1002/pro.4519"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":83,"interactions":0,"matches":4233,"pathways":0,"proteins":3487,"proteomes":1366,"sets":1,"structural_models":{"alphafold":2612},"structures":0,"taxa":3464},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":61,"alignment:full":2880},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}