This family of proteins has no known function however the structure has been determined. The protein consists of two alpha-helices packed on the same side of a central beta-hairpin [[cite:PUB00029976]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00029976":{"PMID":15152082,"ISBN":null,"volume":"13","issue":"6","year":2004,"title":"Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: a novel alpha+beta fold.","URL":null,"raw_pages":"1458-65","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Blanco FJ","Yee A","Campos-Olivas R","Ortiz AR","Devos D","Valencia A","Arrowsmith CH","Rico M."],"DOI_URL":"http://dx.doi.org/10.1110/ps.04620504"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":326,"pathways":0,"proteins":326,"proteomes":326,"sets":0,"structural_models":{"alphafold":313},"structures":2,"taxa":521},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":146},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3ueb","name":"Crystal structure of TON_0450 from Thermococcus onnurineus NA1"}}}