{"metadata":{"accession":"PF11395","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021532","hierarchy":null,"name":{"name":"Betacoronavirus NS7B protein","short":"bCoV_NS7B"},"description":[{"text":"<p>This entry corresponds to Human SARS coronavirus (SARS-CoV) and similar betacoronaviruses  NS7B protein (also known as accessory protein 7b, NS7B, ORF7b and 7b)[[cite:PUB00094107]]. It was found to be a structural component of SARS-CoV virions and an integral membrane protein. Its transmembrane domain is essential for Golgi compartment localization [[cite:PUB00094109]][[cite:PUB00094108]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00094109":{"PMID":18632859,"ISBN":null,"volume":"82","issue":"19","year":2008,"title":"The transmembrane domain of the severe acute respiratory syndrome coronavirus ORF7b protein is necessary and sufficient for its retention in the Golgi complex.","URL":null,"raw_pages":"9477-91","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Schaecher SR","Diamond MS","Pekosz A."],"DOI_URL":null},"PUB00094107":{"PMID":17037516,"ISBN":null,"volume":"581","issue":null,"year":2006,"title":"Structure, expression, and intracellular localization of the SARS-CoV accessory proteins 7a and 7b.","URL":null,"raw_pages":"115-20","medline_journal":"Adv Exp Med Biol","ISO_journal":"Adv. Exp. Med. Biol.","authors":["Pekosz A","Schaecher SR","Diamond MS","Fremont DH","Sims AC","Baric RS."],"DOI_URL":null},"PUB00094108":{"PMID":17079322,"ISBN":null,"volume":"81","issue":"2","year":2007,"title":"The ORF7b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is expressed in virus-infected cells and incorporated into SARS-CoV particles.","URL":null,"raw_pages":"718-31","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Schaecher SR","Mackenzie JM","Pekosz A."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":41,"pathways":0,"proteins":41,"proteomes":3,"sets":0,"structural_models":{"alphafold":2},"structures":0,"taxa":47},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":4},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}