{"metadata":{"accession":"PF11394","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021531","hierarchy":null,"name":{"name":"Type VI lipase adapter protein Tla3, N-terminal","short":"Tla3_N"},"description":[{"text":"<p>This entry represents the N-terminal domain of Type VI lipase adapter protein Tla3, an adapter protein that targets and loads the Tle3 toxin onto the H2 type VI secretion system (H2-T6SS) machinery through an interaction with the TTR domain of VgrG2b [[cite:PUB00100136]] and it seems specific for Tle3 [[cite:PUB00100136]]. This domain and its C-terminal ([pfam:PF20995]) are both required for the interaction with the toxin [[cite:PUB00100136]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100136":{"PMID":31231326,"ISBN":null,"volume":"10","issue":null,"year":2019,"title":"A Type VI Secretion System Trans-Kingdom Effector Is Required for the Delivery of a Novel Antibacterial Toxin in <i>Pseudomonas aeruginosa</i>.","URL":null,"raw_pages":"1218","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Berni B","Soscia C","Djermoun S","Ize B","Bleves S."],"DOI_URL":null}},"set_info":{"accession":"CL0046","name":"Thiolase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":218,"pathways":0,"proteins":218,"proteomes":128,"sets":1,"structural_models":{"alphafold":126},"structures":1,"taxa":209},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":40,"alignment:full":67},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}