{"metadata":{"accession":"PF11382","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021522","hierarchy":null,"name":{"name":"Copper transport outer membrane protein, MctB","short":"MctB"},"description":[{"text":"<p>Outer membrane channel protein MctB in Mycobacterium tuberculosis is part of a Cu resistance mechanism that ensures low intracellular Cu levels in the bacterium. Human resistance to bacteria, mediated via IFN-gamma-mediated activation of macrophages, may involve the use of reactive Cu(1) in the presence of hydrogen peroxide, since activated Cu is toxic to bacteria. IFN-gamma stimulates the trafficking of the Cu transporter ATP7a to the vesicles that fuse with phagosome and these phagosomes are found to have a high Cu content and an increased bactericidal activity against E.coli. Using MctB, Mycobacterium tuberculosis may limit the amount of excess Cu within it whole in the host [[cite:PUB00075654]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075654":{"PMID":21205886,"ISBN":null,"volume":"108","issue":"4","year":2011,"title":"Copper resistance is essential for virulence of Mycobacterium tuberculosis.","URL":null,"raw_pages":"1621-6","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Wolschendorf F","Ackart D","Shrestha TB","Hascall-Dove L","Nolan S","Lamichhane G","Wang Y","Bossmann SH","Basaraba RJ","Niederweis M."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1009261108"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":2398,"pathways":0,"proteins":2374,"proteomes":2353,"sets":0,"structural_models":{"alphafold":1543},"structures":5,"taxa":3169},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":67,"alignment:full":1159},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8au6","name":"Structure of Corynebacterium glutamicum Cg1604, a cell division regulator"}}}