{"metadata":{"accession":"PF11331","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021480","hierarchy":null,"name":{"name":"EDR4 zinc-ribbon domain","short":"Zn_ribbon_12"},"description":[{"text":"<p>This zinc beta ribbon domain is found in Protein ENHANCED DISEASE RESISTANCE 4 (EDR4) and related plant proteins. EDR4 mainly localizes to the plasma membrane and endosomal compartments. It plays a negative role in resistance to powdery mildew and this requires salicylic acid signaling [[cite:PUB00090747]]. In Arabidopsis, EDR4 associates with CLATHRIN HEAVY CHAIN2 (CHC2) and modulates plant immunity by regulating the relocation of EDR1 [[cite:PUB00090747]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00090747":{"PMID":25747881,"ISBN":null,"volume":"27","issue":"3","year":2015,"title":"ENHANCED DISEASE RESISTANCE4 associates with CLATHRIN HEAVY CHAIN2 and modulates plant immunity by regulating relocation of EDR1 in Arabidopsis.","URL":null,"raw_pages":"857-73","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Wu G","Liu S","Zhao Y","Wang W","Kong Z","Tang D."],"DOI_URL":"https://doi.org/10.1105/tpc.114.134668"}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":34,"interactions":0,"matches":2562,"pathways":0,"proteins":2560,"proteomes":375,"sets":1,"structural_models":{"alphafold":2050},"structures":0,"taxa":1026},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":1640},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}