{"metadata":{"accession":"PF11330","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021479","hierarchy":null,"name":{"name":"C-Terminal of 30K viral movement proteins","short":"30K_MP_C_Ter"},"description":[{"text":"<p>This entry represents the C-terminal region found in viral movement proteins (MP) of the 30K type. This region has been suggested to be conserved in secondary structure in Ophioviruses Mps. It contains two parts, (i) a long segment with the potential to form an alpha-helix (alphaB), rich in charged residues, and (ii) a region highly variable in sequence downstream of alphaB. The C-terminal region corresponds to a protease domain which contains a strictly conserved DTG tripeptide also found in related aspartic retroviral proteases. This protease is required for autocleavage of the Movement Protein of ophioviruses in an N-terminal part that supports movement of viral particles through the plant, and this C-terminal part which retains protease activity [[cite:PUB00097831]]. Mutations in the aspartate residue in the core domain [pfam:PF17644] had an impact on cell to cell movement [[cite:PUB00091032]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097831":{"PMID":30135122,"ISBN":null,"volume":"92","issue":"21","year":2018,"title":"Citrus Psorosis Virus Movement Protein Contains an Aspartic Protease Required for Autocleavage and the Formation of Tubule-Like Structures at Plasmodesmata.","URL":null,"raw_pages":null,"medline_journal":"J Virol","ISO_journal":"J Virol","authors":["Robles Luna G","Pena EJ","Borniego MB","Heinlein M","Garcia ML."],"DOI_URL":null},"PUB00091032":{"PMID":27596536,"ISBN":null,"volume":"498","issue":null,"year":2016,"title":"Bioinformatic and mutational analysis of ophiovirus movement proteins, belonging to the 30K superfamily.","URL":null,"raw_pages":"172-180","medline_journal":"Virology","ISO_journal":"Virology","authors":["Borniego MB","Karlin D","Pena EJ","Robles Luna G","Garcia ML."],"DOI_URL":"https://doi.org/10.1016/j.virol.2016.08.027"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":4,"pathways":0,"proteins":4,"proteomes":2,"sets":0,"structural_models":{"alphafold":1},"structures":0,"taxa":15},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":2},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}