{"metadata":{"accession":"PF11325","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021474","hierarchy":null,"name":{"name":"Domain of unknown function (DUF3127)","short":"DUF3127"},"description":[{"text":"<p>This bacterial family of proteins has no known function. However, it does show distant similarity to [pfam:PF00436], with proteins such as [swissprot:D1W984] being similar to both families. This suggests that this family may have a DNA-binding function.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0021","name":"OB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":2398,"pathways":0,"proteins":2398,"proteomes":2260,"sets":1,"structural_models":{"alphafold":1587},"structures":0,"taxa":3154},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":1225},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}