{"metadata":{"accession":"PF11307","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021458","hierarchy":null,"name":{"name":"Rv0495c-like","short":"Rv0495c"},"description":[{"text":"<p>This entry, previously known as DUF3109, represents a bacterial family of probable redox regulatory proteins. A member of this family, Rv0495c, from Mycobacterium tuberculosis is essential for maintaining intracellular redox homeostasis [[cite:PUB00161582]]. Deletion of the Rv0495c gene (delta Rv0495c) results in increased levels of reactive oxygen species and a higher NAD+/NADH ratio, leading to a highly oxidised intracellular state [[cite:PUB00161582]]. Despite showing a growth defect in macrophages, the absence of Rv0495c increases M. tuberculosis pathogenicity in vivo, enhancing the bacterium's ability to proliferate inside the host.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00161582":{"PMID":38211498,"ISBN":null,"volume":"145","issue":null,"year":2024,"title":"Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis.","URL":null,"raw_pages":"102477","medline_journal":"Tuberculosis (Edinb)","ISO_journal":"Tuberculosis (Edinb)","authors":["Pal R","Talwar S","Pandey M","Nain VK","Sharma T","Tyagi S","Barik V","Chaudhary S","Gupta SK","Kumar Y","Nanda R","Singhal A","Pandey AK."],"DOI_URL":"https://doi.org/10.1016/j.tube.2024.102477"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":4353,"pathways":0,"proteins":4347,"proteomes":4310,"sets":0,"structural_models":{"alphafold":2666},"structures":0,"taxa":5507},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":2132},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}