This family of proteins found in plants and cyanobacteria has no known function. The structure of this domain has been solved by NMR for the alr2454 protein [[cite:PUB00061127]]. The structure was determined to be a novel fold composed of four alpha helices and a sheet of three anti-parallel beta-strands.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00061127":{"PMID":22592539,"ISBN":null,"volume":"13","issue":"3","year":2012,"title":"Solution NMR structure of Alr2454 from Nostoc sp. PCC 7120, the first structural representative of Pfam domain family PF11267.","URL":null,"raw_pages":"171-6","medline_journal":"J Struct Funct Genomics","ISO_journal":"J. Struct. Funct. Genomics","authors":["Aramini JM","Petrey D","Lee DY","Janjua H","Xiao R","Acton TB","Everett JK","Montelione GT."],"DOI_URL":"http://dx.doi.org/10.1007/s10969-012-9135-5"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":18,"interactions":0,"matches":895,"pathways":0,"proteins":892,"proteomes":674,"sets":0,"structural_models":{"alphafold":682},"structures":1,"taxa":1903},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":41,"alignment:full":631},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}