{"metadata":{"accession":"PF11251","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024423","hierarchy":null,"name":{"name":"HamA Heme-Oxygenase-like enzyme family","short":"HamA_HO-like"},"description":[{"text":"<p>This entry, previously known as DUF3050, represents HamA, the key enzyme responsible for forming the nitrogen-nitrogen bond in the diazeniumdiolate moiety of fungicide fragin [[cite:PUB00163876]]. HamA adopts a heme oxygenase-like fold, forming a hydrophobic cavity within a helical bundle that likely accommodates the substrate [[cite:PUB00163876]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00163876":{"PMID":41103923,"ISBN":null,"volume":"15","issue":"46","year":2025,"title":"Structural basis of a 2-oxoglutarate-dependent heme-oxygenase-like enzyme HamA in fragin biosynthesis.","URL":null,"raw_pages":"38502-38509","medline_journal":"RSC Adv","ISO_journal":"RSC Adv","authors":["Su B","Zhang T","Yu Y","Liu H."],"DOI_URL":"https://doi.org/10.1039/d5ra05203c"}},"set_info":{"accession":"CL0230","name":"HO"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":1873,"pathways":0,"proteins":1871,"proteomes":1805,"sets":1,"structural_models":{"alphafold":1169},"structures":1,"taxa":2600},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":48,"alignment:full":789},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9vwb","name":"HamA, a Heme-Oxygenase-Like Enzyme"}}}