{"metadata":{"accession":"PF11223","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021386","hierarchy":null,"name":{"name":"SPP41, DUF3020","short":"DUF3020"},"description":[{"text":"<p>This domain is found in the conserved fungal proteins SPP41 (suppressor of PrP4, there are four members, 1 to 4). In S. cerevisiae it is conserved towards the C-terminus of HMG domains. The function is not known. However, it has been shown that SPP41 is involved  in negative regulation of expression of spliceosome components PRP4 and PRP3 and that it relocalizes to the cytosol in response to hypoxia [[cite:PUB00098543],[cite:PUB00098542]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098542":{"PMID":22932476,"ISBN":null,"volume":"2","issue":"1","year":2012,"title":"The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation.","URL":null,"raw_pages":"30","medline_journal":"Cell Biosci","ISO_journal":"Cell Biosci","authors":["Dastidar RG","Hooda J","Shah A","Cao TM","Henke RM","Zhang L."],"DOI_URL":null},"PUB00098543":{"PMID":8005438,"ISBN":null,"volume":"136","issue":"3","year":1994,"title":"Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.","URL":null,"raw_pages":"833-47","medline_journal":"Genetics","ISO_journal":"Genetics","authors":["Maddock JR","Weidenhammer EM","Adams CC","Lunz RL","Woolford JL Jr."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":432,"pathways":0,"proteins":427,"proteomes":253,"sets":0,"structural_models":{"alphafold":293},"structures":0,"taxa":580},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":33,"alignment:full":348},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}