{"metadata":{"accession":"PF11203","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR050051","hierarchy":null,"name":{"name":"Putative type VII ESX secretion system translocon, EccE","short":"EccE"},"description":[{"text":"<p>EccE is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterised in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP [[cite:PUB00083129],[cite:PUB00106938]]. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope [[cite:PUB00083131]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00083131":{"PMID":23541477,"ISBN":null,"volume":"164","issue":"6","year":2013,"title":"Leaving home ain't easy: protein export systems in Gram-positive bacteria.","URL":null,"raw_pages":"664-74","medline_journal":"Res Microbiol","ISO_journal":"Res. Microbiol.","authors":["Freudl R."],"DOI_URL":"http://dx.doi.org/10.1016/j.resmic.2013.03.014"},"PUB00083129":{"PMID":22140496,"ISBN":null,"volume":"6","issue":"11","year":2011,"title":"Computational analysis of the ESX-1 region of Mycobacterium tuberculosis: insights into the mechanism of type VII secretion system.","URL":null,"raw_pages":"e27980","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Das C","Ghosh TS","Mande SS."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pone.0027980"},"PUB00106938":{"PMID":22411983,"ISBN":null,"volume":"367","issue":"1592","year":2012,"title":"Protein secretion and surface display in Gram-positive bacteria.","URL":null,"raw_pages":"1123-39","medline_journal":"Philos Trans R Soc Lond B Biol Sci","ISO_journal":"Philos Trans R Soc Lond B Biol Sci","authors":["Schneewind O","Missiakas DM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":2862,"pathways":0,"proteins":2862,"proteomes":1756,"sets":0,"structural_models":{"alphafold":1681},"structures":7,"taxa":2078},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":45,"alignment:full":1188},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}