{"metadata":{"accession":"PF11195","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021361","hierarchy":null,"name":{"name":"Thoeris anti-defense 2-like domain","short":"Tad2-like"},"description":[{"text":"<p>This entry represents Thoeris anti-defense 2 from Bacillus phage SP01 (Tad2) and similar sequences from tailed bacteriophages and bacterial prophages. Tad2 is an anti-defence protein that counteracts the host Thoeris antiviral defence system. It sequesters the immune signalling molecules produced by Thoeris TIR-domain proteins in response to phage infection [[cite:PUB00153732]]. This entry also includes AcrIIA7 Cas9 inhibitor protein gene.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153732":{"PMID":37992756,"ISBN":null,"volume":"625","issue":"7994","year":2024,"title":"Phages overcome bacterial immunity via diverse anti-defence proteins.","URL":null,"raw_pages":"352-359","medline_journal":"Nature","ISO_journal":"Nature","authors":["Yirmiya E","Leavitt A","Lu A","Ragucci AE","Avraham C","Osterman I","Garb J","Antine SP","Mooney SE","Hobbs SJ","Kranzusch PJ","Amitai G","Sorek R."],"DOI_URL":"https://doi.org/10.1038/s41586-023-06869-w"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":1072,"pathways":0,"proteins":1068,"proteomes":882,"sets":0,"structural_models":{"alphafold":607},"structures":14,"taxa":1758},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":230,"alignment:full":527},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8kbm","name":"Structure of AcrIIA7 complexed with cGG"}}}