{"metadata":{"accession":"PF11175","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021345","hierarchy":null,"name":{"name":"GH172 second beta-sandwich domain","short":"GH172_2nd"},"description":[{"text":"<p>This entry represents a domain found in GH172 family of enzymes including DFA I synthase/hydrolase from Bifidobacterium dentium, Exo-alpha-D-arabinofuranosidase from Microbacterium arabinogalactanolyticum and related proteins [[cite:PUB00161976],[cite:PUB00161977],[cite:PUB00161978]]. These proteins contain a pair of homologous structurally similar domains which adopt jelly-roll beta-sandwich. They assemble into trimeric structure that can form other higher order assemblies.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00161976":{"PMID":37076525,"ISBN":null,"volume":"14","issue":"1","year":2023,"title":"Identification of D-arabinan-degrading enzymes in mycobacteria.","URL":null,"raw_pages":"2233","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Al-Jourani O","Benedict ST","Ross J","Layton AJ","van der Peet P","Marando VM","Bailey NP","Heunis T","Manion J","Mensitieri F","Franklin A","Abellon-Ruiz J","Oram SL","Parsons L","Cartmell A","Wright GSA","Basle A","Trost M","Henrissat B","Munoz-Munoz J","Hirt RP","Kiessling LL","Lovering AL","Williams SJ","Lowe EC","Moynihan PJ."],"DOI_URL":"https://doi.org/10.1038/s41467-023-37839-5"},"PUB00161977":{"PMID":37726269,"ISBN":null,"volume":"14","issue":"1","year":2023,"title":"Identification and characterization of endo-α-, exo-α-, and exo-β-D-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria.","URL":null,"raw_pages":"5803","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Shimokawa M","Ishiwata A","Kashima T","Nakashima C","Li J","Fukushima R","Sawai N","Nakamori M","Tanaka Y","Kudo A","Morikami S","Iwanaga N","Akai G","Shimizu N","Arakawa T","Yamada C","Kitahara K","Tanaka K","Ito Y","Fushinobu S","Fujita K."],"DOI_URL":"https://doi.org/10.1038/s41467-023-41431-2"},"PUB00161978":{"PMID":34688653,"ISBN":null,"volume":"297","issue":"5","year":2021,"title":"Identification of difructose dianhydride I synthase/hydrolase from an oral bacterium establishes a novel glycoside hydrolase family.","URL":null,"raw_pages":"101324","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Kashima T","Okumura K","Ishiwata A","Kaieda M","Terada T","Arakawa T","Yamada C","Shimizu K","Tanaka K","Kitaoka M","Ito Y","Fujita K","Fushinobu S."],"DOI_URL":"https://doi.org/10.1016/j.jbc.2021.101324"}},"set_info":{"accession":"CL0055","name":"Nucleoplasmin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":2840,"pathways":0,"proteins":2808,"proteomes":1816,"sets":1,"structural_models":{"alphafold":1820},"structures":6,"taxa":3198},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":42,"alignment:full":1558},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}