Family members include Cryptococcus neoformans HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains [[cite:PUB00091033]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Tudor_domain","extract":"In molecular biology, a Tudor domain is a conserved protein structural domain originally identified in the Tudor protein encoded in Drosophila. The Tudor gene was found in a Drosophila screen for maternal factors that regulate embryonic development or fertility. Mutations here are lethal for offspring, inspiring the name Tudor, as a reference to the Tudor King Henry VIII and the several miscarriages experienced by his wives.
","thumbnail":null}],"literature":{"PUB00091033":{"PMID":27583447,"ISBN":null,"volume":"12","issue":"9","year":2016,"title":"A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals.","URL":null,"raw_pages":"e1005849","medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog.","authors":["McClelland EE","Ramagopal UA","Rivera J","Cox J","Nakouzi A","Prabu MM","Almo SC","Casadevall A."],"DOI_URL":"https://doi.org/10.1371/journal.ppat.1005849"}},"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":48,"interactions":0,"matches":5242,"pathways":0,"proteins":5238,"proteomes":4414,"sets":1,"structural_models":{"alphafold":3515},"structures":1,"taxa":7010},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":157,"alignment:full":3087},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4p5n","name":"Structure of CNAG_02591 from Cryptococcus neoformans"}}}