{"metadata":{"accession":"PF11145","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021319","hierarchy":null,"name":{"name":"Transmembrane E3 ligase/DUF2921 transmembrane domain","short":"DUF2921"},"description":[{"text":"<p>This entry describes a domain of unknown function, which could adopt a similar fold to the SWEET-like (TM helices) domain. It was found in Transmembrane E3 ubiquitin-proteins and members of the DSC E3 ubiquitin ligase complex. It is predominant in fungi and plants, including the FLY1/2 proteins from Arabidopsis thaliana, the DSC complex protein from Schizosaccharomyces pombe, and TUL1 from Saccharomyces cerevisiae. This domain hasn't been functionally characterised yet but it is formed by seven alpha-helices [[cite:PUB00150892]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00150892":{"PMID":23482858,"ISBN":null,"volume":"25","issue":"3","year":2013,"title":"Flying saucer1 is a transmembrane RING E3 ubiquitin ligase that regulates the degree of pectin methylesterification in Arabidopsis seed mucilage.","URL":null,"raw_pages":"944-59","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Voiniciuc C","Dean GH","Griffiths JS","Kirchsteiger K","Hwang YT","Gillett A","Dow G","Western TL","Estelle M","Haughn GW."],"DOI_URL":null}},"set_info":{"accession":"CL0141","name":"MtN3-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":106,"interactions":0,"matches":5532,"pathways":0,"proteins":4715,"proteomes":1974,"sets":1,"structural_models":{"alphafold":3772},"structures":0,"taxa":4518},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":63,"alignment:full":3911},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}