{"metadata":{"accession":"PF11125","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022599","hierarchy":null,"name":{"name":"Bacteriophage MS2, lysis protein","short":"Phage_MS2_lysis"},"description":[{"text":"<p>This entry represents putative lysis proteins from Bacteriophage MS2 and Bacteriophage BZ13. The bacteriophage MS2 lysin protein swiss:C0M1L5 was identified as an overlapping cistron in the bacteriophage MS2 RNA [[cite:PUB00053761]]. This proteins induces the formation of specific membrane adhesion sites between the inner and outer membranes, apparently leading to host cell lysis. Lysis may be performed via activation of host murein hydrolases [[cite:PUB00097482],[cite:PUB00097483]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097482":{"PMID":2656650,"ISBN":null,"volume":"171","issue":"6","year":1989,"title":"Specific localization of the lysis protein of bacteriophage MS2 in membrane adhesion sites of Escherichia coli.","URL":null,"raw_pages":"3331-6","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Walderich B","Holtje JV."],"DOI_URL":null},"PUB00053761":{"PMID":498271,"ISBN":null,"volume":"18","issue":"2","year":1979,"title":"Binding of mammalian ribosomes to MS2 phage RNA reveals an overlapping gene encoding a lysis function.","URL":null,"raw_pages":"247-56","medline_journal":"Cell","ISO_journal":"Cell","authors":["Atkins JF","Steitz JA","Anderson CW","Model P."],"DOI_URL":"http://dx.doi.org/10.1016/0092-8674(79)90044-8"},"PUB00097483":{"PMID":2653958,"ISBN":null,"volume":"48","issue":"1","year":1989,"title":"Functioning of the cloned phage MS2 lysis protein in Escherichia coli impaired in murein synthesis.","URL":null,"raw_pages":"75-9","medline_journal":"FEMS Microbiol Lett","ISO_journal":"FEMS Microbiol Lett","authors":["Ursinus-Wossner A","Holtje JV."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":23,"pathways":0,"proteins":23,"proteomes":2,"sets":0,"structural_models":{"alphafold":1},"structures":0,"taxa":22},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":2},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}