{"metadata":{"accession":"PF11081","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021304","hierarchy":null,"name":{"name":"Adenovirus L4-33K/L4-22K","short":"Adeno_L433K_22K"},"description":[{"text":"<p>Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K [[cite:PUB00076403]]. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection [[cite:PUB00076403]]. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses [[cite:PUB00076403],[cite:PUB00076401]]. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal [[cite:PUB00076402]]. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression [[cite:PUB00076404],[cite:PUB00144935]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00076403":{"PMID":19176628,"ISBN":null,"volume":"83","issue":"7","year":2009,"title":"Adenovirus serotype 5 L4-22K and L4-33K proteins have distinct functions in regulating late gene expression.","URL":null,"raw_pages":"3049-58","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Morris SJ","Leppard KN."],"DOI_URL":"http://dx.doi.org/10.1128/JVI.02455-08"},"PUB00144935":{"PMID":22811519,"ISBN":null,"volume":"86","issue":"19","year":2012,"title":"The adenovirus L4-22K protein is multifunctional and is an integral component of crucial aspects of infection.","URL":null,"raw_pages":"10474-83","medline_journal":"J Virol","ISO_journal":"J Virol","authors":["Wu K","Orozco D","Hearing P."],"DOI_URL":null},"PUB00076402":{"PMID":16809303,"ISBN":null,"volume":"80","issue":"14","year":2006,"title":"The L4 22-kilodalton protein plays a role in packaging of the adenovirus genome.","URL":null,"raw_pages":"6973-81","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Ostapchuk P","Anderson ME","Chandrasekhar S","Hearing P."],"DOI_URL":"http://dx.doi.org/10.1128/JVI.00123-06"},"PUB00076401":{"PMID":17028184,"ISBN":null,"volume":"281","issue":"48","year":2006,"title":"L4-33K, an adenovirus-encoded alternative RNA splicing factor.","URL":null,"raw_pages":"36510-7","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Tormanen H","Backstrom E","Carlsson A","Akusjarvi G."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M607601200"},"PUB00076404":{"PMID":2363740,"ISBN":null,"volume":"33","issue":"6","year":1990,"title":"Decreased activity of Reiter's syndrome after urethrectomy.","URL":null,"raw_pages":"885-7","medline_journal":"Arthritis Rheum","ISO_journal":"Arthritis Rheum.","authors":["Rubin RA","Goldfarb RA","Lidsky MD","Abrams J."],"DOI_URL":"http://dx.doi.org/10.1002/art.1780330617"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":285,"pathways":0,"proteins":270,"proteomes":131,"sets":0,"structural_models":{"alphafold":162},"structures":0,"taxa":381},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":69},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}