This uncharacterised domain is found at the C-terminal in Uncharacterized protein MG366, Uncharacterized protein UU173 and related bacteria. UU173 is encoded next to an element that encodes UU172 [Swissprot:Q9PQX1], a phase-variable surface membrane protein paralogous to multiple-banded antigen (MBA) [[cite:PUB00159629]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00159629":{"PMID":21255110,"ISBN":null,"volume":"79","issue":"3","year":2011,"title":"Ureaplasma antigenic variation beyond MBA phase variation: DNA inversions generating chimeric structures and switching in expression of the MBA N-terminal paralogue UU172.","URL":null,"raw_pages":"663-76","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Zimmerman CU","Rosengarten R","Spergser J."],"DOI_URL":"https://doi.org/10.1111/j.1365-2958.2010.07474.x"}},"set_info":{"accession":"CL0219","name":"RNase_H"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":904,"pathways":0,"proteins":903,"proteomes":847,"sets":1,"structural_models":{"alphafold":654},"structures":0,"taxa":1818},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":59,"alignment:full":578},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}