This is a family of short uncharacterised proteins predominantly found in bacteria. This model matches four of the twelve transmembrane helices of cytochrome c and quinol oxidase subunit I ([pfam:PF00115]) and contains the HxH motif conserved in both. A DALI search suggests that this family may be related to Cox1, however, there is no evidence for the involvement of this family in any Cox1-like assembly. AlphaFold prediction suggests that these proteins contain four transmembrane alpha helices which can for a homotrimeric complex.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0714","name":"COX1-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":914,"pathways":0,"proteins":914,"proteomes":859,"sets":1,"structural_models":{"alphafold":576},"structures":0,"taxa":1357},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":436},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}