{"metadata":{"accession":"PF11004","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021266","hierarchy":null,"name":{"name":"3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase","short":"Kdo_hydroxy"},"description":[{"text":"<p>This is a family of 3-deoxy-D-manno-oct-2-ulosonic acid 3-hydroxylases, which catalyse the conversion of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) to D-glycero-D-talo-oct-2-ulosonic acid (Ko). It contains a potential iron-binding motif, HXDX(n)H (n>40). Hydroxylation activity is iron-dependent [[cite:PUB00057446]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00057446":{"PMID":21178073,"ISBN":null,"volume":"108","issue":"2","year":2011,"title":"Dioxygenases in Burkholderia ambifaria and Yersinia pestis that hydroxylate the outer Kdo unit of lipopolysaccharide.","URL":null,"raw_pages":"510-5","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Chung HS","Raetz CR."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1016462108"}},"set_info":{"accession":"CL0029","name":"Cupin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":698,"pathways":0,"proteins":698,"proteomes":693,"sets":1,"structural_models":{"alphafold":450},"structures":7,"taxa":995},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":298},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5y9x","name":"Crystal structure of the Kdo hydroxylase KdoO, a non-heme Fe(II) alphaketoglutarate dependent dioxygenase in complex with alphaketoglutarate and coblat(II)"}}}