{"metadata":{"accession":"PF11001","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR047092","hierarchy":null,"name":{"name":"YDR124W-like, helical bundle domain","short":"AFUB_07903_YDR124W_hel"},"description":[{"text":"<p>This entry represents mitochondrial proteins from fungi, such as subtelomeric hrmA-associated cluster protein AFUB_079030 from Aspergillus fumigatus and YDR124W from yeast. Null mutant showed severe fragmentation of mitochondria and its expression is strongly induced by alpha factor. These proteins may have a role in maintenance of mitochondrial morphology [[cite:PUB00101836]]. This entry represents an helical bundle domain which seems to adopt a similar arrangement than the EIN3-like DNA-binding domain (Based on structural comparison, DALI server). AFUB_079030 is part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarised growing filaments [[cite:PUB00153731]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153731":{"PMID":31548684,"ISBN":null,"volume":"4","issue":"12","year":2019,"title":"Fungal biofilm morphology impacts hypoxia fitness and disease progression.","URL":null,"raw_pages":"2430-2441","medline_journal":"Nat Microbiol","ISO_journal":"Nat Microbiol","authors":["Kowalski CH","Kerkaert JD","Liu KW","Bond MC","Hartmann R","Nadell CD","Stajich JE","Cramer RA."],"DOI_URL":"https://doi.org/10.1038/s41564-019-0558-7"},"PUB00101836":{"PMID":31945465,"ISBN":null,"volume":"112","issue":"3","year":2020,"title":"Predicting subcellular localization of proteins using protein-protein interaction data.","URL":null,"raw_pages":"2361-2368","medline_journal":"Genomics","ISO_journal":"Genomics","authors":["Garapati HS","Male G","Mishra K."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":26,"interactions":0,"matches":1722,"pathways":0,"proteins":1718,"proteomes":1067,"sets":0,"structural_models":{"alphafold":1429},"structures":0,"taxa":2117},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":80,"alignment:full":1329},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}